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- Hirsch, Vanessa M., et al. Show all 25 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.8 pp. 2975-2980
- DNA; DNA viruses; Human immunodeficiency virus; Macaca; Simian immunodeficiency virus; T-lymphocytes; animals; antibodies; antigens; cytotoxicity; genotype; humoral immunity; immune response; immunoglobulin G; recombinant vaccines; vaccination; vaccine development; viremia; virion; virus replication; viruses
- ... We have previously shown that macaques vaccinated with DNA vectors expressing SIVmac239 antigens developed potent immune responses able to reduce viremia upon high-dose SIVmac251 challenge. To further improve vaccine-induced immunity and protection, we combined the SIVmac239 DNA vaccine with protein immunization using inactivated SIVmac239 viral particles as protein source. Twenty-six weeks after ...
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