Jump to Main Content
- Kim, Hee-Kwon, et al. Show all 5 Authors
- ACS applied materials 2013 v.5 no.12 pp. 5648-5658
- DNA; biodegradability; cytotoxicity; drugs; ethers; ethylene glycol; hydrolysis; lipids; pH; polyethylene glycol; sulfates; transfection
- ... Novel pH-responsive assemblies (PEG-lipid:DOPE liposomes) containing tunable and bifunctional phenyl-substituted vinyl ether (PIVE) cross-linkers were prepared. The assemblies consisted of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), acid-cleavable poly(ethylene glycol) (PEG)-conjugated lipids, pDNA, and protamine sulfate (PS). The PIVE linkage was designed to hydrolyze under acidic condi ...