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1. Activity-Guided Discovery of (S)-Malic Acid 1′-O-β-Gentiobioside as an Angiotensin I-Converting Enzyme Inhibitor in Lettuce (Lactuca sativa)

Author:
Lagemann, Annika; Dunkel, Andreas; Hofmann, Thomas
Source:
Journal of agricultural and food chemistry 2012 v.60 no.29 pp. 7211-7217
ISSN:
1520-5118
Subject:
Lactuca sativa; aldosterone; angiotensin I; angiotensin II; antihypertensive agents; blood pressure; fractionation; functional foods; glycosidases; glycosides; hydrochloric acid; hydrolysis; inhibitory concentration 50; ion exchange chromatography; lettuce; nuclear magnetic resonance spectroscopy; peptidyl-dipeptidase A; phytochemicals; renin; saliva; stomach
Abstract:
... Angiotensin-converting enzyme (ACE), playing a crucial role in the renin angiotensin aldosterone system, is well-known to catalyze the conversion of the decapeptide angiotensin I into the physiologically active octapeptide angiotensin II, triggering blood pressure increasing mechanisms. To meet the demand for natural phytochemicals as antihypertensive agents in functional food development, extract ...
DOI:
10.1021/jf3022157
PubMed:
22762370