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- Thakar, Amit; Sylar, Elise; Flynn, Francis W.
- Peptides 2012 v.38 no.2 pp. 282-290
- G-protein coupled receptors, etc ; DNA; acetylation; agonists; cell growth; chromatin; gene expression; gene expression regulation; genes; histones; nervous system; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; Show all 14 Subjects
- ... The tachykinin, neurokinin 3 receptor (NK3R) is a g-protein coupled receptor that is broadly distributed in the nervous system and exerts its diverse physiological actions through multiple signaling pathways. Despite the role of the receptor system in a range of biological functions, the effects of NK3R activation on chromatin dynamics and gene expression have received limited attention. The prese ...
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- Oakley, Robert H.; Revollo, Javier; Cidlowski, John A.
- Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.43 pp. 17591-17596
- G-protein coupled receptors, etc ; adenocarcinoma; arrestins; complement; drugs; gene expression; genes; glucocorticoid receptors; glucocorticoids; human diseases; humans; inositols; mice; mitogen-activated protein kinase; phosphates; plasma membrane; proteinases; response elements; scaffolding proteins; signal transduction; Show all 20 Subjects
- ... G protein-coupled receptors (GPCRs) compose the largest family of cell surface receptors and are the most common target of therapeutic drugs. The nonvisual arrestins, β-arrestin-1 and β-arrestin-2, are multifunctional scaffolding proteins that play critical roles in GPCR signaling. On binding of activated GPCRs at the plasma membrane, β-arrestins terminate G protein-dependent responses (desensitiz ...
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