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- Du, Juan, et al. Show all 3 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.11 pp. 4140-4145
- adenine; adenosine triphosphate; bioinformatics; crystal structure; models; molecular dynamics; receptors
- ... P2X receptors are trimeric ATP-gated cation channels participating in diverse physiological processes. How ATP binding triggers channel opening remains unclear. Here the gating mechanism of a P2X receptor was studied by normal mode analysis and molecular dynamics (MD) simulations. Based on the resting-state crystal structure, a normal mode involving coupled motions of three β-strands (β1, β13, and ...
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