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1. In Vitro Exposure of Acer negundo Pollen to Atmospheric Levels of SO2 and NO2: Effects on Allergenicity and Germination

Author:
Ribeiro, Helena,   et al.   ; Sousa, Raquel; Duque, Laura; Duarte, Abel J.; Gomes, Carlos R.; Cruz, Ana; Esteves da Silva, Joaquim C. G.; Abreu, Ilda;     Show all 8 Authors
Source:
Environmental Science & Technology 2012 v.46 no.4 pp. 2406-2412
ISSN:
1520-5851
Subject:
Acer negundo; air pollution; allergenicity; germination; hay fever; health promotion; human health; immunoglobulin E; nitrogen dioxide; patients; plant reproduction; pollen; polyacrylamide gel electrophoresis; polypeptides; protein content; sulfur dioxide; urban areas; Europe
Abstract:
... In the last years, a rising trend of pollen allergies in urban areas has been attributed to atmospheric pollution. In this work, we investigated the effects of SO₂ and NO₂ on the protein content, allergenicity, and germination rate of Acer negundo pollen. A novel environmental chamber was assembled to exposure pollen samples with SO₂ or NO₂ at two different levels: just below and two times the atm ...
DOI:
10.1021/es2034685

2. Endothelial dysfunction in the pulmonary artery induced by concentrated fine particulate matter exposure is associated with local but not systemic inflammation

Author:
Farsky, Sandra Helena,   et al.   ; Davel, Ana Paula; Lemos, Miriam; Pastro, Luciana Manfré; Pedro, Sibelli Cosme; de André, Paulo Afonso; Hebeda, Cristina; Saldiva, Paulo Hilário; Rossoni, Luciana Venturini;     Show all 9 Authors
Source:
Toxicology 2012 v.295 no.1-3 pp. 39-46
ISSN:
0300-483X
Subject:
acetylcholine; adults; air; air pollution; blood cells; breathing; coagulation; endothelial nitric oxide synthase; inflammation; nitric oxide; oxidative stress; particulates; protein synthesis; pulmonary artery; rats; superoxide dismutase; toxicology; tumor necrosis factor-alpha
Abstract:
... Clinical evidence has identified the pulmonary circulation as an important target of air pollution. It was previously demonstrated that in vitro exposure to fine particulate matter (aerodynamic diameter ≤2.5μm, PM₂.₅) induces endothelial dysfunction in isolated pulmonary arteries. We aimed to investigate the effects of in vivo exposure to urban concentrated PM₂.₅ on rat pulmonary artery reactivity ...
DOI:
10.1016/j.tox.2012.02.004