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- Tu, Zhidan, et al. Show all 31 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.34 pp. 13757-13762
- alleles; angiogenesis; apolipoprotein B; cardiovascular diseases; complement; epithelium; eyes; gene expression; genome-wide association study; genotype; humans; inflammation; macrophages; macular degeneration; mice; oxidative stress; oxygen; phospholipids; risk; solar radiation
- ... The rs1061170T/C variant encoding the Y402H change in complement factor H (CFH) has been identified by genome-wide association studies as being significantly associated with age-related macular degeneration (AMD). However, the precise mechanism by which this CFH variant impacts the risk of AMD remains largely unknown. Oxidative stress plays an important role in many aging diseases, including cardi ...
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