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- Du, Juan, et al. Show all 6 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.45 pp. 18395-18400
- Salmonella Typhimurium; X-ray diffraction; anions; aquaporins; crystal structure; cytotoxins; electrophysiology; formates; innate immunity; intestinal microorganisms; lipid bilayers; macrophages; nitric oxide; nitrites; nitrogen metabolism; pH; pathogenicity; protein subunits
- ... Nitrite (NO ₂⁻) is a central intermediate in the nitrogen metabolism of microorganisms and plants, and is used as a cytotoxin by macrophages as part of the innate immune response. The bacterial membrane protein NirC acts as a specific channel to facilitate the transport of nitrite anions across lipid bilayers for cytoplasmic detoxification. Despite NirC’s importance in nitrogen metabolism and in t ...
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