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1. Proteomic Identification of Common SCF Ubiquitin Ligase FBXO6-Interacting Glycoproteins in Three kinds of Cells

Author:
Wu, Ying-Li,   et al.   ; Liu, Bin; Zheng, Ying; Wang, Tong-Dan; Xu, Han-Zhang; Xia, Li; Zhang, Jian; Chen, Guo-Qiang; Wang, Li-Shun;     Show all 9 Authors
Source:
Journal of Proteome Research 2012 v.11 no.3 pp. 1773-1781
ISSN:
1535-3907
Subject:
F-box proteins; cell lines; databases; glycoproteins; liquid chromatography; mass spectrometry; mutants; proteomics; ubiquitin-protein ligase; ubiquitination
Abstract:
... FBOX6 ubiquitin ligase complex is involved in the endoplasmic reticulum-associated degradation pathway by mediating the ubiquitination of glycoproteins. FBXO6 interacts with the chitobiose in unfolded N-glycoprotein, pointing glycoproteins toward E2 for ubiquitination. Although the glycoprotein-recognizing mechanism of FBXO6 is well documented, its bona fide interacting glycoproteins are largely u ...
DOI:
10.1021/pr2010204