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- Zhu, Xiao-Lei, et al. Show all 9 Authors
- Journal of the American Chemical Society 2012 v.134 no.27 pp. 11168-11176
- binding capacity; chickens; crystal structure; cytochrome c; drugs; fungicides; membrane proteins; screening; swine; ubiquinol-cytochrome-c reductase
- ... A critical challenge to the fragment-based drug discovery (FBDD) is its low-throughput nature due to the necessity of biophysical method-based fragment screening. Herein, a method of pharmacophore-linked fragment virtual screening (PFVS) was successfully developed. Its application yielded the first picomolar-range Qₒ site inhibitors of the cytochrome bc₁ complex, an important membrane protein for ...