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- Umland, Timothy C.; Schultz, L. Wayne; MacDonald, Ulrike; Beanan, Janet M.; Olson, Ruth; Russo, Thomas A.
- mBio 2012 v.3 no.4 pp. e00113-12
- rats, etc ; Acinetobacter baumannii; DNA; Enterobacter; Escherichia coli; Gram-negative bacteria; Klebsiella pneumoniae; Pseudomonas aeruginosa; RNA; abscess; anti-infective agents; ascites; culture media; databases; drugs; essential genes; humans; models; mutants; pathogens; protein transport; screening; Show all 22 Subjects
- ... A critical feature of a potential antimicrobial target is the characteristic of being essential for growth and survival during host infection. For bacteria, genome-wide essentiality screens are usually performed on rich laboratory media. This study addressed whether genes detected in that manner were optimal for the identification of antimicrobial targets since the in vivo milieu is fundamentally ...
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