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- Takada, Ayato, et al. Show all 7 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.42 pp. 17040-17045
- Influenza A virus; antibodies; antigenic variation; antiviral properties; binding sites; crystal structure; hemagglutinins; humans; immunoglobulin G; influenza; mutation; neutralization; vaccines; viruses
- ... Continual and rapid mutation of seasonal influenza viruses by antigenic drift necessitates the almost annual reformulation of flu vaccines, which may offer little protection if the match to the dominant circulating strain is poor. S139/1 is a cross-reactive antibody that neutralizes multiple HA strains and subtypes, including those from H1N1 and H3N2 viruses that currently infect humans. The cryst ...
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