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- Umland, Timothy C.; Schultz, L. Wayne; MacDonald, Ulrike; Beanan, Janet M.; Olson, Ruth; Russo, Thomas A.
- mBio 2012 v.3 no.4 pp. e00113-12
- rats, etc ; Acinetobacter baumannii; DNA; Enterobacter; Escherichia coli; Gram-negative bacteria; Klebsiella pneumoniae; Pseudomonas aeruginosa; RNA; abscess; anti-infective agents; ascites; culture media; databases; drugs; essential genes; humans; models; mutants; pathogens; protein transport; screening; Show all 22 Subjects
- ... A critical feature of a potential antimicrobial target is the characteristic of being essential for growth and survival during host infection. For bacteria, genome-wide essentiality screens are usually performed on rich laboratory media. This study addressed whether genes detected in that manner were optimal for the identification of antimicrobial targets since the in vivo milieu is fundamentally ...
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- Cao, Ping; Tu, Ling-Hsien; Abedini, Andisheh; Levsh, Olesya; Akter, Rehana; Patsalo, Vadim; Schmidt, Ann Marie; Raleigh, Daniel P.
- Journal of molecular biology 2012 v.421 no.2-3 pp. 282-295
- rats, etc ; amyloid; humans; missense mutation; models; mutants; noninsulin-dependent diabetes mellitus; polypeptides; risk; toxicity; transmission electron microscopy; Show all 11 Subjects
- ... Islet amyloid polypeptide (IAPP, amylin) is responsible for amyloid formation in type 2 diabetes and in islet cell transplants. The only known natural mutation found in mature human IAPP is a Ser20-to-Gly missense mutation, found with small frequency in Chinese and Japanese populations. The mutation appears to be associated with increased risk of early-onset type 2 diabetes. Early measurements in ...
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