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You searched for: Subject "glucagon-like peptides" Remove constraint Subject: "glucagon-like peptides" Publication Year 2012 Remove constraint Publication Year: 2012 Subject noninsulin-dependent diabetes mellitus Remove constraint Subject: noninsulin-dependent diabetes mellitus Subject cytotoxicity Remove constraint Subject: cytotoxicity
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1. Dynamic monitoring of β-cell injury with impedance and rescue by glucagon-like peptide-1

Author:
Guan, Ni; Gao, Weiwei; He, Min; Zheng, Min; Xu, Xiao; Wang, Xiaobo; Wang, Ming-Wei
Source:
Analytical biochemistry 2012 v.423 no.1 pp. 61-69
ISSN:
0003-2697
Subject:
glucagon-like peptide 1,   etc   ; diagnostic techniques; islets of Langerhans; monitoring; cytotoxicity; free fatty acids; hydrogen peroxide; physiology; cytokines; toxic substances; bioassays; streptozotocin; noninsulin-dependent diabetes mellitus;     Show all 13 Subjects
Abstract:
... β-Cell injury plays an important role in the development of type 1 and type 2 diabetes. Most of the β-cell bioassays depend on labeling or endpoint assessments that might not capture the true physiology or pathology of the injury process. In the current study, we dynamically detected a broad range of pathological and pharmacological responses to four toxicants (cytokine mixture, free fatty acid mi ...
DOI:
10.1016/j.ab.2012.01.014

2. Efficient GLP-1 gene delivery using two-step transcription amplification plasmid system with a secretion signal peptide and arginine-grafted bioreducible polymer

Author:
Kim, Tae-il; Lee, Minhyung; Kim, Sung Wan
Source:
Journal of controlled release 2012 v.157 no.2 pp. 243-248
ISSN:
0168-3659
Subject:
glucagon-like peptide 1,   etc   ; cytotoxicity; enzyme-linked immunosorbent assay; genes; insulin; noninsulin-dependent diabetes mellitus; plasmids; polymers; reverse transcriptase polymerase chain reaction; secretion; signal peptide; therapeutics; transcription (genetics); transfection; zeta potential;     Show all 15 Subjects
Abstract:
... Glucagon-like peptide (GLP-1) encoding dual plasmid (pDNA) system (TSTA (SP-GLP-1)) which is composed of pβ-Gal4-p65 and pUAS-SP-GLP-1 was constructed to improve the production and secretion of expressed GLP-1 by combining the advantages of signal peptide (SP) and two-step transcription amplification (TSTA) system. Its potential for GLP-1 gene delivery system was investigated with employment of ar ...
DOI:
10.1016/j.jconrel.2011.09.072
PubMed:
21945681
PubMed Central:
PMC3248954