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- Tóth, Balázs; Csanády, László
- Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.33 pp. 13440-13445
- transient receptor potential channels, etc ; adenosine diphosphate; apoptosis; calcium; insulin secretion; ions; ligands; mutation; oxidative stress; phagocytes; ribose; Show all 11 Subjects
- ... The Ca ²⁺-permeable cation channel transient receptor potential melastatin 2 (TRPM2) plays a key role in pathogen-evoked phagocyte activation, postischemic neuronal apoptosis, and glucose-evoked insulin secretion, by linking these cellular responses to oxidative stress. TRPM2 channels are coactivated by binding of intracellular ADP ribose and Ca ²⁺ to distinct cytosolically accessible sites on the ...
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- Ma, Xin; Cai, Yanfei; He, Dongxu; Zou, Chang; Zhang, Peng; Lo, Chun Yin; Xu, Zhenyu; Chan, Franky L.; Yu, Shan; Chen, Yun; Zhu, Ruiyu; Lei, Jianyong; Jin, Jian; Yao, Xiaoqiang
- Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.40 pp. 16282-16287
- transient receptor potential channels, etc ; T-lymphocytes; animal models; breast neoplasms; calcium; cytotoxicity; doxorubicin; drug therapy; humans; multiple drug resistance; neoplasm cells; transcription factors; Show all 12 Subjects
- ... An attractive strategy to overcome multidrug resistance in cancer chemotherapy is to suppress P-glycoprotein (P-gp), which is a pump overproduced in cancer cells to remove cytotoxic drugs from cells. In the present study, a Ca ²⁺-permeable channel TRPC5 was found to be overproduced together with P-gp in adriamycin-resistant breast cancer cell line MCF-7/ADM. Suppressing TRPC5 activity/expression r ...
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