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- Casas, Meritxell Galindo, et al. Show all 21 Authors
- Journal of molecular biology 2012 v.420 no.3 pp. 204-219
- antibodies; humans; hybridomas; immune response; immunoglobulin G; point mutation; therapeutics
- ... Bispecific antibodies and antibody fragments are a new class of therapeutics increasingly utilized in the clinic for T cell recruitment (catumaxomab anti-EpCAM/CD3 and blinatumomab anti-CD19/CD3), increase in the selectivity of targeting, or simultaneous modulation of multiple cellular pathways. While the clinical potential for certain bispecific antibody formats is clear, progress has been hinder ...