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- Verplaetse, Emilie, et al. Show all 4 Authors
- Biochemical and biophysical research communications 2012 v.424 no.4 pp. 781-785
- Trypanosoma brucei; glycolysis; microbodies; protein transport; receptors; topology
- ... Trypanosoma brucei contains peroxisome-like organelles designated glycosomes because they sequester the major part of the glycolytic pathway. Import of proteins into the peroxisomal matrix involves a protein complex associated with the peroxisomal membrane of which PEX13 is a component. Two very different PEX13 isoforms have recently been identified in T. brucei. A striking feature of one of the i ...
- Verplaetse, Emilie, et al. Show all 8 Authors
- International journal for parasitology 2012 v.42 no.4 pp. 401-409
- Trypanosoma brucei; antiserum; bloodstream forms; cell motility; flagellum; fluorescent antibody technique; fractionation; hexokinase; insects; locomotion; metabolites; microbodies; parasites; phosphorylation; polypeptides; recombinant proteins; viability
- ... The majority of the glycolytic enzymes in the African trypanosome are compartmentalised within peroxisome-like organelles, the glycosomes. Polypeptides harbouring peroxisomal targeting sequences (PTS type 1 or 2) are targeted to these organelles. This targeting is essential to parasite viability, as compartmentalisation of glycolytic enzymes prevents unregulated ATP-dependent phosphorylation of in ...