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- Wright, Ernest M., et al. Show all 4 Authors
- Biochemistry 2012 v.51 no.47 pp. 9480-9487
- amino acids; binding sites; carbohydrate binding; glucose; hydrogen bonding; inositols; mutants; sodium; solutes; stoichiometry; symporters
- ... In the LeuT family of sodium solute symporters, 13–17% of the residues in transmembrane domains are aromatic. The unique properties of aromatic amino acids allow them to play specialized roles in proteins, but their function in membrane transporters is underappreciated. Here we analyze the π bonding pattern in the LeuT (5TMIR) family and then describe the role of a triad of aromatic residues in so ...
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