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1. Evidence for an evolutionary antagonism between Mrr and Type III modification systems

Author:
Wywial, Ewa,   et al.   ; Tesfazgi Mebrhatu, Mehari; Ghosh, Anirban; Michiels, Chris W.; Lindner, Ariel B.; Taddei, François; Bujnicki, Janusz M.; Van Melderen, Laurence; Aertsen, Abram;     Show all 9 Authors
Source:
Nucleic acids research 2011 v.39 no.14 pp. 5991-6001
ISSN:
0305-1048
Subject:
DNA; Escherichia coli; Salmonella Typhimurium; antagonism; databases; epigenetics; genes; genotoxicity; loci; methyltransferases; restriction endonucleases; screening
Abstract:
... The Mrr protein of Escherichia coli is a laterally acquired Type IV restriction endonuclease with specificity for methylated DNA. While Mrr nuclease activity can be elicited by high-pressure stress in E. coli MG1655, its (over)expression per se does not confer any obvious toxicity. In this study, however, we discovered that Mrr of E. coli MG1655 causes distinct genotoxicity when expressed in Salmo ...
DOI:
10.1093/nar/gkr219
PubMed:
21504983
PubMed Central:
PMC3152355