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1. Antiosteoporotic compounds from seeds of Cuscuta chinensis

Author:
Zhang, Guolin,   et al.   ; Yang, Lijuan; Chen, Qianfeng; Wang, Fei;     Show all 4 Authors
Source:
Journal of ethnopharmacology 2011 v.135 no.2 pp. 553-560
ISSN:
0378-8741
Subject:
Cuscuta; agonists; alkaline phosphatase; antagonists; cell proliferation; estrogenic properties; estrogens; gene expression; isorhamnetin; kaempferol; osteoporosis; quercetin; response elements; seeds; sodium phosphate
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: The seeds of Cuscuta chinensis (Tu–Si–Zi, TSZ) have long been used for the treatment of osteoporosis in China and some Asian countries. The compounds in TSZ responsible for the antiosteoporotic activity are still poorly understood. AIM OF THE STUDY: The present study was designed to investigate the osteogenic compounds in TSZ, and to evaluate their antiosteoporotic ...
DOI:
10.1016/j.jep.2011.03.056
PubMed:
21463675

2. Anti-hyperglycemic, antioxidant and anti-inflammatory effects of VIP and a VPAC1 agonist on streptozotocin-induced diabetic mice

Author:
Zhang, HuaHua,   et al.   ; Yu, Rongjie; Huang, Lin; Liu, Xiaofei; Chen, Jiansu;     Show all 5 Authors
Source:
Peptides 2011 v.32 no.2 pp. 216-222
ISSN:
0196-9781
Subject:
pancreas; anti-inflammatory activity; vasoactive intestinal peptide; diabetes mellitus; intraperitoneal injection; oxidative stress; immunohistochemistry; malondialdehyde; hydrogen peroxide; spleen; oxidation; interleukin-10; hyperglycemia; transcription factor NF-kappa B; body weight; blood glucose; glycemic effect; fasting; mice; tumor necrosis factor-alpha; insulin; antioxidant activity; glucose tolerance; histopathology; food intake; liver; inflammation; streptozotocin; agonists
Abstract:
... Vasoactive intestinal peptide (VIP) is a pleiotropic neuropeptide with potent anti-inflammatory properties, and its receptor, VPAC1, mediates most of the anti-inflammatory effects of VIP. Diabetes mellitus is characterized by increased oxidation and inflammation due to persistent hyperglycemia. This research was performed to investigate the effects of VIP and a VPAC1 agonist on streptozotocin (STZ ...
DOI:
10.1016/j.peptides.2010.11.017

3. Osthole ameliorates insulin resistance by increment of adiponectin release in high-fat and high-sucrose-induced fatty liver rats

Author:
Zhang, Yan,   et al.   ; Qi, Zhigang; Xue, Jie; Wang, Hengbin; Xie, Meilin;     Show all 5 Authors
Source:
Planta medica 2011 v.77 no.3 pp. 231-235
ISSN:
0032-0943
Subject:
adiponectin; agonists; animal models; blood glucose; blood serum; cholesterol; fasting; fatty liver; free fatty acids; homeostasis; inflammation; insulin; insulin resistance; liver; rats; triacylglycerols; weight gain
Abstract:
... The objectives of this study were to determine the effect of osthole on the insulin resistance (IR) in high-fat and high-sucrose-induced fatty liver rats and to investigate its potential mechanisms. The rat model was established by orally feeding high-fat and high-sucrose emulsion by gavage for 9 weeks. The experimental rats were treated with osthole 5 and 10 mg/kg, lipanthyl 30 mg/kg, and rosigli ...
DOI:
10.1055/s-0030-1250268
PubMed:
20717873

4. Jerdonuxin, a novel snaclec (snake C-type lectin) with platelet aggregation activity from Trimeresurus jerdonii venom

Author:
Zhang, Yong; Zhang, Yun,   et al.   ; Chen, Zhong-Ming; Wu, Jian-Bo; Yu, Guo-Yu; Lee, Wen-Hui; Lu, Qiu-Min;     Show all 7 Authors
Source:
Toxicon 2011 v.57 no.1 pp. 109-116
ISSN:
0041-0101
Subject:
Trimeresurus; agonists; amino acids; bioactive properties; blood; complementary DNA; glycoproteins; humans; lectins; metalloproteinases; molecular weight; nucleotide sequences; phosphorylation; platelet aggregation; polyacrylamide gel electrophoresis; polyclonal antibodies; serine proteinases; signal peptide; snakes; venoms
Abstract:
... Serious clinical symptoms of Trimeresurus jerdonii bite are mainly caused by abnormalities of blood system. We have previously identified and characterized several bioactive components affecting human blood system, such as serine proteases, metalloproteinases and disintegrins. But few snaclec was characterized in the T. jerdonii venom. In this study, a novel snaclec, named jerdonuxin, was isolated ...
DOI:
10.1016/j.toxicon.2010.10.011

5. Protective effect of the peroxisome proliferator-activated receptor (PPAR)-γ, ligand rosiglitazone on tert-butyl hydroperoxide-induced QZG cell injury

Author:
Zhang, Xiao-Di; Zhang, Wei,   et al.   ; Li, Wen-Li; Liang, Xin; Wang, Xin; Liu, Rui; Chen, Hong-Li; Qin, Xu-Jun; Bai, Hua; Hai, Chun-Xu;     Show all 10 Authors
Source:
Experimental and toxicologic pathology 2011 v.63 no.6 pp. 527-533
ISSN:
0940-2993
Subject:
agonists; apoptosis; cell viability; chromatin; cilia; flow cytometry; gene expression regulation; light microscopy; necrosis; oxidative stress; protective effect; reverse transcriptase polymerase chain reaction; stress response; toxicity; transcription factors
Abstract:
... Tert-butyl hydroperoxide (t-BHP) can induce cell injury by forming free radical intermediates. Peroxisome proliferator-activated receptor (PPAR)-γ is a ligand-activated transcription factor belonging to nuclear hormone receptor superfamily, and is involved in oxidative stress response. Thiazolidinedione rosiglitazone is a potent PPARγ agonist. The main aim of this study was to investigate the prot ...
DOI:
10.1016/j.etp.2010.04.003

6. Development of a novel DnaE intein-based assay for quantitative analysis of G-protein-coupled receptor internalization

Author:
Zhang, Yaping,   et al.   ; Yang, Wen; Chen, Linjie; Shi, Ying; Li, Guo; Zhou, Naiming;     Show all 6 Authors
Source:
Analytical biochemistry 2011 v.417 no.1 pp. 65-72
ISSN:
0003-2697
Subject:
G-protein coupled receptors; Nostoc punctiforme; agonists; antagonists; drugs; luciferase; quantitative analysis; screening
Abstract:
... G-protein-coupled receptor (GPCR) internalization provides a G-protein-subtype-independent method for assaying agonist-stimulated activation of receptors. We have developed a novel assay that allows quantitative analysis of GPCR internalization based on the interaction between activated GPCRs and β-arrestin2 and on Nostoc punctiforme DnaE intein-mediated reconstitution of Renilla luciferase fragme ...
DOI:
10.1016/j.ab.2011.06.005

7. An Assessment of Androgenic/Anti-androgenic Effects of GH Transgenic Carp by Hershberger Assay

Author:
ZHANG, WenZhong,   et al.   ; LIU, YuMei; YONG, Ling; ZHAO, XiaoHong; JIA, XuDong; LI, Ning;     Show all 6 Authors
Source:
Biomedical and environmental sciences 2011 v.24 no.4 pp. 445-449
ISSN:
0895-3988
Subject:
accessory sex glands; agonists; antagonists; blood serum; body weight; carp; follicle-stimulating hormone; luteinization; luteinizing hormone; males; oral administration; propionic acid; rats; screening; solvents; somatotropin; testosterone; transgenic animals
Abstract:
... OBJECTIVE: To evaluate the androgenic and anti-androgenic effects of GH (growth hormone) transgenic carp in male rats. METHODS: Hershberger assay was carried out in castrated male SD rats aged 4-5 weeks. Testosterone propionate (TP) (0.4 mg/kg BW) was administrated for a positive control, GH transgenic carp (3.0 g/kg BW)+TP (0.4 mg/kg BW), parental carp (3.0 g/kg BW) + TP (0.4 mg/kg BW), and fluta ...
DOI:
10.3967/0895-3988.2011.04.017

8. Cimetidine augments Th1/Th2 dual polarized immune responses to recombinant HBV antigens

Author:
Zhang, Wenjuan,   et al.   ; Wang, Junpeng; Su, Baowei; Li, Ruiguo; Ding, Zheng; Kang, Youmin; Wang, Bin;     Show all 7 Authors
Source:
Vaccine 2011 v.29 no.29-30 pp. 4862-4868
ISSN:
0264-410X
Subject:
T-lymphocytes; agonists; alum; antacids; antigens; cell-mediated immunity; cimetidine; cytotoxicity; gastric acid; histamine; humans; immune response; immunization; immunomodulators; interleukin-10; signal transduction; vaccines
Abstract:
... Cimetidine (CIM) is a histamine H2 receptor inverse agonist used primarily as an anti-stomach acids drug, but recent studies showed that it may also modulate immune responses. To evaluate its potential usefulness as an adjuvant, we determined its immune modulating effects on subunit immunization using an HBV-derived recombinant protein antigen rHBsAg. CIM activated the PI3K-Akt signaling pathway i ...
DOI:
10.1016/j.vaccine.2011.03.091

9. Inhibitory effects of processed Aconiti tuber on morphine-induced conditioned place preference in rats

Author:
Zhang, Hui,   et al.   ; Wu, Guiyun; Huang, Wenqi; Li, Qiaobo; Zhou, Jun; Shu, Haihua;     Show all 6 Authors
Source:
Journal of ethnopharmacology 2011 v.136 no.1 pp. 254-259
ISSN:
0378-8741
Subject:
agonists; analgesic effect; herbal medicines; morphine; rats; receptors; tubers
Abstract:
... AIM OF THE STUDY: Our previous studies indicated that processed Aconiti tuber (PAT), a traditional Chinese herbal medicine, had antinociceptive effects and inhibitory effects on morphine tolerance by activation of kappa-opioid receptor (KOR). Preclinical studies also demonstrated that KOR agonists functionally attenuate addictive behaviors of morphine, such as conditioned place preference (CPP). T ...
DOI:
10.1016/j.jep.2011.04.041
PubMed:
21549821

10. Regulation of Ca²⁺-entry in pancreatic α-cell line by transient receptor potential melastatin 4 plays a vital role in glucagon release

Author:
Zhang, H.,   et al.   ; Nelson, P.L.; Zolochevska, O.; Figueiredo, M.L.; Soliman, A.; Hsu, W.H.; Feng, J.M.; Cheng, H.;     Show all 8 Authors
Source:
Molecular and cellular endocrinology 2011 v.335 no.2 pp. 126-134
ISSN:
0303-7207
Subject:
agonists; calcium; gene expression; glucagon; glucose; homeostasis; image analysis; immunocytochemistry; islets of Langerhans; patch-clamp technique; protein synthesis; reverse transcriptase polymerase chain reaction; secretion
Abstract:
... Elevation in the intracellular Ca²⁺ concentration stimulates glucagon secretion from pancreatic α-cells. The Transient Receptor Potential Melastatin 4 channel (TRPM4) is critical for Ca²⁺ signaling. However, its role in glucagon secreting α-cells has not been investigated. We identified TRPM4 gene expression and protein in the αTC1-6 cell line using RT-PCR and immunocytochemistry. Furthermore, we ...
DOI:
10.1016/j.mce.2011.01.007

11. Structure Basis of Bigelovin as a Selective RXR Agonist with a Distinct Binding Mode

Author:
Zhang, Haitao,   et al.   ; Li, Li; Chen, Lili; Hu, Lihong; Jiang, Hualiang; Shen, Xu;     Show all 6 Authors
Source:
Journal of molecular biology 2011 v.407 no.1 pp. 13-20
ISSN:
0022-2836
Subject:
agonists; crystal structure; homeostasis; humans; metabolic diseases; steroid receptors; transcriptional activation; triacylglycerols
Abstract:
... The nuclear receptor retinoid X receptor (RXR) functions potently in the regulation of homeostasis and cell development, while rexinoids as RXR agonists have proved their therapeutic potential in the treatment of metabolic diseases and cancer. Here, the natural product bigelovin was identified as a selective RXRα agonist. Interestingly, this compound could not transactivate RXRα:RXRα homodimer but ...
DOI:
10.1016/j.jmb.2011.01.032
PubMed:
21262235

12. Involvement of calcium-sensing receptor in inhibition of lipolysis through intracellular cAMP and calcium pathways in human adipocytes

Author:
Zhang, Huaqi,   et al.   ; He, Yonghan; Teng, Jianghua; Huang, Lina; Li, Ying; Sun, Changhao;     Show all 6 Authors
Source:
Biochemical and biophysical research communications 2011 v.404 no.1 pp. 393-399
ISSN:
0006-291X
Subject:
adenosine monophosphate; adipocytes; adipose tissue; agonists; antagonists; blood; cAMP-dependent protein kinase; calcium; cyclic AMP; gene expression; gene silencing; humans; lipolysis; messenger RNA; receptors; small interfering RNA; translation (genetics)
Abstract:
... The calcium-sensing receptor (CaSR) was cloned initially from the bovine parathyroid and its primary physiological role is maintaining constant blood Ca²⁺ levels. Subsequently, CaSR was found to be expressed in human adipose tissue, however, its physiological functions remain unclear. In this study, the effect of CaSR on lipolysis and the mechanisms by which it functions were explored in SW872 cel ...
DOI:
10.1016/j.bbrc.2010.11.129
PubMed:
21130730

13. Adenosine A₂AR modulates cardiovascular function by activating ERK1/2 signal in the rostral ventrolateral medulla of acute myocardial ischemic rats

Author:
Zhang, Chengrong,   et al.   ; Jiang, Meiyan; Wang, Jin; Chen, Jun; Xia, Chunmei; Du, Dongshu; Zhao, Na; Cao, Yinxiang; Shen, Linlin; Zhu, Danian;     Show all 10 Authors
Source:
Life sciences 2011 v.89 no.5-6 pp. 182-187
ISSN:
0024-3205
Subject:
Western blotting; adenosine; agonists; animal models; antagonists; coronary vessels; heart rate; immunohistochemistry; messenger RNA; mitogen-activated protein kinase; neurons; phosphorylation; protein synthesis; quantitative polymerase chain reaction; rats; receptors
Abstract:
... AIMS: To investigate the cardiovascular regulatory mechanism of adenosine A₂A receptor (A₂AR) in the rostral ventrolateral medulla (RVLM) in acute myocardial ischemic (AMI) rats. MAIN METHODS: The animal model of AMI was established by ligating the left anterior descending coronary artery (LAD). The A₂AR expression was examined by immunohistochemistry, western blot and real-time PCR. CGS21680 and ...
DOI:
10.1016/j.lfs.2011.06.003

14. In vitro enhanced differentiation of neural networks in ES gut-like organ from mouse ES cells by a 5-HT₄-receptor activation

Author:
Zhang, Guo-Xing,   et al.   ; Takaki, Miyako; Misawa, Hiromi; Matsuyoshi, Hiroko; Kawahara, Isao; Goto, Kei; Obata, Koji; Kuniyasu, Hiroki;     Show all 8 Authors
Source:
Biochemical and biophysical research communications 2011 v.406 no.4 pp. 529-533
ISSN:
0006-291X
Subject:
agonists; citrates; digestive system; gene expression; gene expression regulation; messenger RNA; mice; myocytes; neural networks; serotonin; smooth muscle; tyrosine
Abstract:
... Using an embryoid body (EB) culture system, we developed a functional organ-like cluster, a “gut”, from mouse embryonic stem (ES) cells (ES gut). Each ES gut exhibited various types of spontaneous movements. In these spontaneously contracting ES guts, dense distributions of interstitial cells of Cajal (ICC) (c-kit, a transmembrane receptor that has tyrosine kinase activity, positive cells; gut pac ...
DOI:
10.1016/j.bbrc.2011.02.072

15. Bioanalytical and instrumental analysis of thyroid hormone disrupting compounds in water sources along the Yangtze River

Author:
Zhang, Xiaowei,   et al.   ; Shi, Wei; Wang, Xiaoyi; Hu, Guanjiu; Hao, Yingqun; Liu, Hongling; Wei, Si; Wang, Xinru; Yu, Hongxia;     Show all 9 Authors
Source:
Environmental pollution 2011 v.159 no.2 pp. 441-448
ISSN:
0269-7491
Subject:
agonists; antagonists; bioassays; dibutyl phthalate; fibroblasts; kidneys; monkeys; reporter genes; thyroid hormones; China; Yangtze River
Abstract:
... Thyroid hormone (TH) agonist and antagonist activities of water sources along the Yangtze River in China were surveyed by a green monkey kidney fibroblast (CV-1) cell-based TH reporter gene assay. Instrumental analysis was conducted to identify the responsible thyroid-active compounds. Instrumentally derived l-3,5,3′-triiodothyronine (T₃) equivalents (T₃-EQs) and thyroid receptor (TR) antagonist a ...
DOI:
10.1016/j.envpol.2010.10.023
PubMed:
21074918

16. Induction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery

Author:
Zhang, Zhiping,   et al.   ; Tongchusak, Songsak; Mizukami, Yo; Kang, Yoon Joong; Ioji, Tetsuya; Touma, Maki; Reinhold, Bruce; Keskin, Derin B.; Reinherz, Ellis L.; Sasada, Tetsuro;     Show all 10 Authors
Source:
Biomaterials 2011 v.32 no.14 pp. 3666-3678
ISSN:
0142-9612
Subject:
T-lymphocytes; Toll-like receptor 4; agonists; animal models; anticarcinogenic activity; antigen presentation; antigens; biodegradability; cytotoxicity; dendritic cells; emulsions; fluorescence; interferon-gamma; lipid A; melanoma; mice; nanoparticles; neoplasm cells; peptides; vaccination; vaccine development
Abstract:
... Nanotechnology-based antigen delivery has been developing as a vaccine strategy due to its dose-sparing and prolonged antigen presentation features. In the current study, we examined the feasibility of nanoparticle (NP)-mediated delivery of antigenic peptides to efficiently induce cytotoxic T lymphocyte responses against tumor-associated self-antigens in C57BL/6 mouse models. The biodegradable pol ...
DOI:
10.1016/j.biomaterials.2011.01.067

17. U50,488H postconditioning reduces apoptosis after myocardial ischemia and reperfusion

Author:
Zhang, Quanyu,   et al.   ; Tong, Guang; Sun, Zhongchan; Wei, Xufeng; Gu, Chunhu; Kaye, Alan David; Wang, Yuemin; Li, Juan; Guo, Haitao; Yu, Shiqiang; Yi, Dinghua; Pei, Jianming;     Show all 12 Authors
Source:
Life sciences 2011 v.88 no.1-2 pp. 31-38
ISSN:
0024-3205
Subject:
agonists; antagonists; apoptosis; cardiomyocytes; death; endothelial nitric oxide synthase; in vitro studies; infarction; myocardial ischemia; nitric oxide; phosphatidylinositol 3-kinase; phosphorylation; rats
Abstract:
... AIMS: Evidence has indicated U50,488H, a selective κ-opioid receptor (κ-OR) agonist, administered before ischemia attenuates apoptosis and infarction during ischemia and reperfusion (I/R). However, it remains unclear whether U50,488H postconditioning reduces apoptosis during I/R. This study was designed, therefore, to test the hypothesis that U50,488H administered at the onset of reperfusion inhib ...
DOI:
10.1016/j.lfs.2010.10.018