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- Capell, Brian C., et al. Show all 9 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2011 v.108 no.12 pp. 4997-5002
- aneuploidy; antineoplastic activity; centrosomes; chromatin; drugs; geranylgeranyl diphosphate synthase; mechanism of action; mice; mitosis; neoplasm cells; tissues
- ... Despite the success of protein farnesyltransferase inhibitors (FTIs) in the treatment of certain malignancies, their mode of action is incompletely understood. Dissecting the molecular pathways affected by FTIs is important, particularly because this group of drugs is now being tested for the treatment of Hutchinson-Gilford progeria syndrome. In the current study, we show that FTI treatment causes ...
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