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- Schaffer, David V., et al. Show all 2 Author
- Cell 2011 v.144 no.6 pp. 844-849
- cell physiology; evolution; genome; genomics; metabolism; models; new technology
- ... A decade ago, seminal perspectives and papers set a strong vision for the field of systems biology, and a number of these themes have flourished. Here, we describe key technologies and insights that have elucidated the evolution, architecture, and function of cellular networks, ultimately leading to the first predictive genome-scale regulatory and metabolic models of organisms. Can systems approac ...
- Schaffer, David V., et al. Show all 4 Authors
- Trends in biotechnology 2011 v.29 no.10 pp. 517-525
- chromatin; drug resistance; epigenetics; eukaryotic cells; gene expression; genes; phenotypic variation; population; transcription (genetics); virulence
- ... Gene expression noise is a significant source of phenotypic heterogeneity in otherwise identical populations of cells. Phenotypic heterogeneity can cause reversible drug resistance in diseased cells, and thus a better understanding of its origins might improve treatment strategies. In eukaryotes, data strongly suggest that intrinsic noise arises from transcriptional bursts caused by slow, random t ...