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- Cheatham, S. Christian, et al. Show all 9 Authors
- International journal of antimicrobial agents 2011 v.37 no.1 pp. 46-50
- Monte Carlo method; Pseudomonas aeruginosa; anti-infective agents; blood serum; drug therapy; half life; minimum inhibitory concentration; pathogens; patients; pharmacokinetics; probability; United States
- ... The objective of this study was to evaluate the steady-state pharmacokinetics and pharmacodynamics of cefepime administered by prolonged infusion in hospitalised patients requiring antimicrobial therapy. Nine patients received 1g every 8h (q8h), infused over 4h, and steady-state pharmacokinetic parameters were determined by non-compartmental and compartmental methods. Using these pharmacokinetic p ...