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- Díaz-San Segundo, Fayna, et al. Show all 4 Authors
- Veterinary research 2011 v.42 no.1 pp. 27
- Foot-and-mouth disease virus; RNA; blood; carrier state; pathogenicity; quantitative analysis; ruminants; swine; viremia; viruses
- ... Foot-and-mouth disease virus (FMVD), one of the most contagious viruses of cloven-hoofed animals, may cause a prolonged, asymptomatic but persistent infection in ruminants, named the "carrier state". However, it remains an open question whether this carrier state occurs in pigs. Here we present quantitative analyses of the duration of FMDV RNA and infectivity in lymphoid and epithelial tissues in ...
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- Diaz-San Segundo, Fayna, et al. Show all 5 Authors
- Journal of interferon & cytokine research 2011 v.31 no.2 pp. 227
- swine; Foot-and-mouth disease virus; serotypes; foot-and-mouth disease; immunity; vaccination; live vaccines; genetic vectors; Adenoviridae; genes; interferons; intramuscular injection
- ... Foot-and-mouth disease virus (FMDV) causes a highly contagious disease of cloven-hoofed animals. Current inactivated vaccines require approximately 7 days to induce protection, but before this time vaccinated animals remain susceptible to disease. Previously, we demonstrated that intramuscular (IM) inoculation of a replication-defective human adenovirus type 5 (Ad5) vector containing a porcine int ...
- Díaz-San Segundo, Fayna, et al. Show all 7 Authors
- Virology 2011 v.413 no.2 pp. 283
- immune response; interferons; gene expression regulation; antiviral properties; Foot-and-mouth disease virus; foot-and-mouth disease; cattle diseases; host-pathogen relationships
- ... Foot-and-mouth disease (FMD) is one of the most serious threats to the livestock industry. Despite the availability of a vaccine, recent outbreaks in disease-free countries have demonstrated that development of novel FMD control strategies is imperative. Here we report the identification and characterization of bovine (bo) interferon lambda 3 (IFN-λ3), a member of the type III IFN family. Expressi ...