PubAg

Main content area

You searched for: Author "Liu, Ye V." Remove constraint Author: "Liu, Ye V." Publication Year 2011 Remove constraint Publication Year: 2011
Start Over

Search

1  Search Results

1 entry found
Number of results to display per page

Search Results

1. Chimeric severe acute respiratory syndrome coronavirus (SARS-CoV) S glycoprotein and influenza matrix 1 efficiently form virus-like particles (VLPs) that protect mice against challenge with SARS-CoV

Author:
Liu, Ye V.,   et al.   ; Massare, Michael J.; Barnard, Dale L.; Kort, Thomas; Nathan, Margret; Wang, Lei; Smith, Gale;     Show all 7 Authors
Source:
Vaccine 2011 v.29 no.38 pp. 6606-6613
ISSN:
0264-410X
Subject:
Severe acute respiratory syndrome coronavirus; aluminum hydroxide; chimerism; death; glycoproteins; immune response; influenza; insects; mice; models; neutralizing antibodies; pandemic; people; viral load; virus-like particle vaccines; virus-like particles; weight loss
Abstract:
... SARS-CoV was the cause of the global pandemic in 2003 that infected over 8000 people in 8 months. Vaccines against SARS are still not available. We developed a novel method to produce high levels of a recombinant SARS virus-like particles (VLPs) vaccine containing the SARS spike (S) protein and the influenza M1 protein using the baculovirus insect cell expression system. These chimeric SARS VLPs h ...
DOI:
10.1016/j.vaccine.2011.06.111
PubMed:
21762752
PubMed Central:
PMC3165014