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- Winter, Rolf, et al. Show all 6 Authors
- Experimental parasitology 2011 v.127 no.2 pp. 545-551
- Plasmodium falciparum; humans; multiple drug resistance; models; microsomes; mice; polyethylene glycol; structure-activity relationships; parasitology; rats; malaria; oral administration; quinolones; antimalarials
- ... Our prior work on tricyclic acridones combined with a desire to minimize the tricyclic system led to an interest in antimalarial quinolones and a reexamination of endochin, an experimental antimalarial from the 1940’s. In the present article, we show that endochin is unstable in the presence of murine, rat, and human microsomes which may explain its relatively poor antimalarial activity in mammali ...
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