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- Choder, Mordechai, et al. Show all 6 Authors
- Cell 2011 v.147 no.7 pp. 1473-1483
- DNA; cytoplasm; messenger RNA; promoter regions; reporter genes; transactivators; yeasts
- ... Promoters are DNA elements that enable transcription and its regulation by trans-acting factors. Here, we demonstrate that yeast promoters can also regulate mRNA decay after the mRNA leaves the nucleus. A conventional yeast promoter consists of a core element and an upstream activating sequence (UAS). We find that changing UASs of a reporter gene without altering the transcript sequence affects th ...
- Amster-Choder, Orna, et al. Show all 4 Authors
- Science 2011 v.331 no.6020 pp. 1081-1084
- Escherichia coli; bacteria; cytoplasm; membrane proteins; messenger RNA; protein products; translation (genetics)
- ... Understanding the organization of a bacterial cell requires the elucidation of the mechanisms by which proteins localize to particular subcellular sites. Thus far, such mechanisms have been suggested to rely on embedded features of the localized proteins. Here, we report that certain messenger RNAs (mRNAs) in Escherichia coli are targeted to the future destination of their encoded proteins, cytopl ...