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1. Differential regulation of full-length genome and a single-stranded 7S DNA along the cell cycle in human mitochondria

Author:
Tappin, Inger,   et al.   ; Antes, Anita; Chung, Stella; Lim, Robert; Lu, Bin; Parrott, Andrew M.; Hill, Helene Z.; Suzuki, Carolyn K.; Lee, Chee-Gun;     Show all 9 Authors
Source:
Nucleic acids research 2010 v.38 no.19 pp. 6466-6476
ISSN:
0305-1048
Subject:
DNA replication; genome; humans; in vitro studies; interphase; mitochondria; mitochondrial DNA
Abstract:
... Mammalian mitochondria contain full-length genome and a single-stranded 7S DNA. Although the copy number of mitochondrial DNA (mtDNA) varies depending on the cell type and also in response to diverse environmental stresses, our understanding of how mtDNA and 7S DNA are maintained and regulated is limited, partly due to lack of reliable in vitro assay systems that reflect the in vivo functionality ...
DOI:
10.1093/nar/gkq493
PubMed:
20530535
PubMed Central:
PMC2965228