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- Schaffer, David V., et al. Show all 4 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2010 v.107 no.28 pp. 12475-12480
- Murine leukemia virus; RNA-directed DNA polymerase; carcinogenesis; engineering; gene expression; genome; humans; insertional mutagenesis; mutants; retroviral vectors; transcription (genetics); zinc finger motif
- ... Retroviral vectors offer benefits of efficient delivery and stable gene expression; however, their clinical use raises the concerns of insertional mutagenesis and potential oncogenesis due to genomic integration preferences in transcriptional start sites (TSS). We have shifted the integration preferences of retroviral vectors by generating a library of viral variants with a DNA-binding domain inse ...
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