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- Kuklin, Nelly A., et al. Show all 13 Authors
- Nucleic acids research 2010 v.38 no.2 pp. 660-671
- RNA interference; apolipoprotein B; double-stranded RNA; messenger RNA; nucleosides; phosphates; phosphorylation; ribose; small interfering RNA
- ... Small interfering RNAs (siRNAs) are short, double-stranded RNAs that use the endogenous RNAi pathway to mediate gene silencing. Phosphorylation facilitates loading of a siRNA into the Ago2 complex and subsequent cleavage of the target mRNA. In this study, 2', 3' seco nucleoside modifications, which contain an acylic ribose ring and are commonly called unlocked nucleic acids (UNAs), were evaluated ...
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