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- Henis-Korenblit, Sivan, et al. Show all 7 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2010 v.107 no.21 pp. 9730-9735
- Caenorhabditis elegans; endoplasmic reticulum; gene expression; genes; homeostasis; longevity; messenger RNA; mutants; proteins; ribonucleases; stress response; stress tolerance; transcription factors; unfolded protein response
- ... When unfolded proteins accumulate in the endoplasmic reticulum (ER), the unfolded protein response is activated. This ER stress response restores ER homeostasis by coordinating processes that decrease translation, degrade misfolded proteins, and increase the levels of ER-resident chaperones. Ribonuclease inositol-requiring protein-1 (IRE-1), an endoribonuclease that mediates unconventional splicin ...
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