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- Pereira, Jorge A., et al. Show all 9 Authors
- Science 2010 v.328 no.5984 pp. 1415-1418
- Schwann cells; animal models; axons; chromosomes; mice; myelin sheath; myelination; nerve tissue; peripheral nervous system diseases
- ... The thickness of the myelin sheath that insulates axons is fitted for optimal nerve conduction velocity. Here, we show that, in Schwann cells, mammalian disks large homolog 1 (Dlg1) interacts with PTEN (phosphatase and tensin homolog deleted on chromosome 10) to inhibit axonal stimulation of myelination. This mechanism limits myelin sheath thickness and prevents overmyelination in mouse sciatic ne ...