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- Stricher, François, et al. Show all 6 Authors
- Nucleic acids research 2010 v.38 no.21 pp. 7422-7431
- DNA; algorithms; eyes; missense mutation; models; protein-protein interactions; transcription (genetics); transcription factors
- ... Quite often a single or a combination of protein mutations is linked to specific diseases. However, distinguishing from sequence information which mutations have real effects in the protein's function is not trivial. Protein design tools are commonly used to explain mutations that affect protein stability, or protein-protein interaction, but not for mutations that could affect protein-DNA binding. ...
- PubMed Central:
- Stricher, Francois, et al. Show all 7 Authors
- Nucleic acids research 2010 v.38 no.suppl_1 pp. D545
- data collection; databases; drugs; information retrieval; ligands; models; nucleic acids; peptides; sequence homology
- ... Although protein-peptide interactions are estimated to constitute up to 40% of all protein interactions, relatively little information is available for the structural details of these interactions. Peptide-mediated interactions are a prime target for drug design because they are predominantly present in signaling and regulatory networks. A reliable data set of nonredundant protein-peptide complexe ...