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- Marino, Stephen F.
- FEBS journal 2009 v.276 no.16 pp. 4515-4528
- G-protein coupled receptors, etc ; G-proteins; agonists; antagonists; binding sites; crystallization; crystals; guanine nucleotides; hydrolysis; hydrophilicity; mammals; plasma membrane; proteolysis; screening; signal transduction; surface area; Show all 16 Subjects
- ... Elucidation of the molecular details of signal transduction through G-protein coupled receptors (GPCRs) awaits the solution of high-resolution structures of the receptor species involved in passing the extracellular information across the plasma membrane. The critical challenge in this effort is the production of sufficient quantities of active and homogeneous receptor species amenable to crystall ...