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- Chung, Soo Yeon; Han, Ah-Reum; Sung, Min Kyung; Jung, Ho Jin; Nam, Joo-Won; Seo, Eun-Kyoung; Lee, Hwa Jeong
- Phytotherapy research 2009 v.23 no.4 pp. 472-476
- Zingiber montanum, etc ; drug therapy; humans; multiple drug resistance; verapamil; rhizomes; breast neoplasms; Show all 7 Subjects
- ... Five phenylbutenoid derivatives from the rhizomes of Zingiber cassumunar Roxb. (Zingiberaceae) were evaluated for their P-glycoprotein (P-gp) inhibitory effects in a P-gp over-expressing multidrug resistant (MDR) human breast cancer cell line, MCF-7/ADR. As a result, a phenylbutenoid dimer, (±)-trans-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene (1), exhibited highly potent P-g ...