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1. Inhibition of Apoptosis in Cryptosporidium parvum-Infected Intestinal Epithelial Cells Is Dependent on Survivin

Author:
Rutherford, Mark S.,   et al.   ; Liu, Jin; Enomoto, Shinichiro; Lancto, Cheryl A.; Abrahamsen, Mitchell S.;     Show all 5 Authors
Source:
Infection and immunity 2008 v.76 no.8 pp. 3784-3792
ISSN:
0019-9567
Subject:
Cryptosporidium parvum; apoptosis; caspase-2; epithelial cells; gene expression; gene expression regulation; genes; humans; intestinal mucosa; parasites; proteins; ribosomal RNA
Abstract:
... Cryptosporidium parvum is an obligate intracellular protozoan capable of causing severe diarrheal disease in a wide variety of mammals, including humans. C. parvum infection has been associated with induction of apoptosis in exposed epithelial cells, and we now demonstrate that apoptosis is restricted to a subset of cells actively infected with C. parvum. Approximately 20% of the infected cells un ...
DOI:
10.1128/IAI.00308-08
PubMed:
18519556
PubMed Central:
PMC2493198