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- Birsoy, Kıvanç; Soukas, Alexander; Torrens, Javier; Ceccarini, Giovanni; Montez, Jason; Maffei, Margherita; Cohen, Paul; Fayzikhodjaeva, Gulnorakhon; Viale, Agnes; Socci, Nicholas D.; Friedman, Jeffrey M.
- Proceedings of the National Academy of Sciences of the United States of America 2008 v.105 no.35 pp. 12985-12990
- recombinant DNA, etc ; adipocytes; carbohydrate metabolism; leptin; glycogen; luciferase; glycerol; triacylglycerols; weight loss; biochemical pathways; gene expression; acetyl coenzyme A; lipogenesis; adipose tissue; transgenic animals; reporter genes; mice; promoter regions; Show all 18 Subjects
- ... The cellular program responsible for the restoration of adipose tissue mass after weight loss is largely uncharacterized. Leptin mRNA levels are highly correlated with adipose tissue mass, and leptin expression can thus be used as a surrogate for changes in the amount of adipose tissue. To further study the responses of adipocytes to changes in weight, we created a transgenic mouse expressing the ...
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