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- DeMichele, Angela, et al. Show all 33 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2008 v.105 no.19 pp. 7004-7009
- animal ovaries; biomarkers; chromosomes; comparative genomic hybridization; complementary DNA; epigenetics; gene expression regulation; genomics; humans; microRNA; microarray technology; non-coding RNA; ovarian neoplasms; transcription (genetics); tumor suppressor genes
- ... MicroRNAs (miRNAs) are an abundant class of small noncoding RNAs that function as negative gene regulators. miRNA deregulation is involved in the initiation and progression of human cancer; however, the underlying mechanism and its contributions to genome-wide transcriptional changes in cancer are still largely unknown. We studied miRNA deregulation in human epithelial ovarian cancer by integrativ ...
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