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- Bouffard, Pascal, et al. Show all 18 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2008 v.105 no.9 pp. 3521-3526
- RNA; RNA editing; adenocarcinoma; complementary DNA; databases; epigenetics; genes; lungs; mesothelioma; patients; point mutation; sequence analysis; tissues; transcriptomics
- ... Cancers arise by the gradual accumulation of mutations in multiple genes. We now use shotgun pyrosequencing to characterize RNA mutations and expression levels unique to malignant pleural mesotheliomas (MPMs) and not present in control tissues. On average, 266 Mb of cDNA were sequenced from each of four MPMs, from a control pulmonary adenocarcinoma (ADCA), and from normal lung tissue. Previously o ...
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