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- Stricher, François, et al. Show all 5 Authors
- Nucleic acids research 2008 v.36 no.7 pp. 2163-2173
- DNA; algorithms; computers; dimerization; engineering; genetic engineering; genome; homologous recombination; nucleotide sequences; scaffolding proteins
- ... Meganucleases cut long (>12 bp) unique sequences in genomes and can be used to induce targeted genome engineering by homologous recombination in the vicinity of their cleavage site. However, the use of natural meganucleases is limited by the repertoire of their target sequences, and considerable efforts have been made to engineer redesigned meganucleases cleaving chosen targets. Homodimeric meganu ...
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