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- Tarpey, Patrick, et al. Show all 23 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.46 pp. 18163-18168
- central nervous system diseases; comparative genomic hybridization; humans; males; memory; models; mutants; mutation; protein folding; receptors; synaptic transmission
- ... Ionotropic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (iGluRs) mediate the majority of excitatory synaptic transmission in the CNS and are essential for the induction and maintenance of long-term potentiation and long-term depression, two cellular models of learning and memory. We identified a genomic deletion (0.4 Mb) involving the entire GRIA3 (encoding iGluR3) by usin ...
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