Jump to Main Content
- Roychowdhury, Abhijit, et al. Show all 3 Authors
- Infection and immunity 2007 v.75 no.2 pp. 706-713
- agonists; gene expression; immune evasion; innate immunity; intracellular signaling peptides and proteins; lipopolysaccharides; pathogens; peptidoglycans; receptors; secretion; synergism; tripeptides; tumor necrosis factor-alpha
- ... Nucleotide-binding oligomerization domain (NOD) protein 1 (NOD1) and NOD2 are pathogen recognition receptors that sense breakdown products of peptidoglycan (PGN) (muropeptides). It is shown that a number of these muropeptides can induce tumor necrosis factor alpha (TNF-α) gene expression without significant TNF-α translation. This translation block is lifted when the muropeptides are coincubated w ...
- PubMed Central: