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- Henis-Korenblit, Sivan, et al. Show all 3 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.14 pp. 5947-5952
- Caenorhabditis elegans; adults; genes; homeostasis; longevity; mutants; proteasome endopeptidase complex; proteins; somatic cells; transcription (genetics); transcription factors; ubiquitin-protein ligase
- ... The proteasome maintains cellular homeostasis by degrading oxidized and damaged proteins, a function known to be impaired during aging. The proteasome also acts in a regulatory capacity through E3 ligases to mediate the spatially and temporally controlled breakdown of specific proteins that impact biological processes. We have identified components of a Skp1-Cul1-F-Box E3 ligase complex that are r ...
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