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- Wiersinga, W. Joost; Wieland, Catharina W.; van der Windt, Gerritje J.W.; de Boer, Anita; Florquin, Sandrine; Dondorp, Arjen; Day, Nicholas P.; Peacock, Sharon J.; van der Poll, Tom
- Infection and immunity 2007 v.75 no.8 pp. 3739-3746
- saprophytes, etc ; Burkholderia pseudomallei; binding proteins; blood; immune response; interferon-gamma; interleukin-18; kidneys; lethal dose; lungs; melioidosis; messenger RNA; mice; microbial growth; mortality; pathogenesis; patients; soil; South East Asia; Show all 19 Subjects
- ... Melioidosis is caused by the soil saprophyte Burkholderia pseudomallei and is endemic in Southeast Asia. The pathogenesis of melioidosis is still largely unknown, although gamma interferon (IFN-γ) seems to play an obligatory role in host defense. Previously, we have shown that IFN-γ production in melioidosis is controlled in part by interleukin-18 (IL-18). The aim of the present study was to deter ...
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