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- Singh, Sudha B.; Davis, Alexander S.; Taylor, Gregory A.; Deretic, Vojo
- Science 2006 v.313 no.5792 pp. 1438-1441
- autophagy, etc ; Mycobacterium tuberculosis; guanosinetriphosphatase; humans; mice; organelles; pathogens; Show all 7 Subjects
- ... Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a human IRG protein in the control of intracellul ...
- Sarafian, Victoria S.; Marinova, Tsvetana T.
- Acta biologica Hungarica 2006 v.57 no.3 pp. 315-322
- autophagy, etc ; apoptosis; epithelial cells; gene expression regulation; glycoproteins; humans; immunohistochemistry; lymphocytes; lysosomes; macrophages; models; quantitative analysis; thymus gland; Show all 13 Subjects
- ... The lysosomal membrane-associated glycoproteins LAMP-1 and LAMP-2 are the major constituents of lysosomal membranes with still undefined biological functions. As autophagy is an alternative model of programmed cell death in which lysosomes play a crucial role, we hypothesize that LAMPs might participate in this phenomenon in the involuting thymus. Thymic glands from cases with acute (infection ind ...