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- Spiliotis, Elias T.; Kinoshita, Makoto; Nelson, W. James
- Science 2005 v.307 no.5716 pp. 1781-1785
- chromosome elimination, etc ; G-proteins; chromosome segregation; cytokinesis; kinetochores; mammals; metaphase; mitosis; polymerization; Show all 9 Subjects
- ... Coordination of cytokinesis with chromosome congression and segregation is critical for proper cell division, but the mechanism is unknown. Here, septins, a conserved family of polymerizing guanosine triphosphate-binding proteins, localized to the metaphase plate during mitosis. Septin depletion resulted in chromosome loss from the metaphase plate, lack of chromosome segregation and spindle elonga ...
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