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- Okuno, M., et al. Show all 10 Authors
- Nutrition and cancer 2005 v.51 no.2 pp. 197-206
- carcinogenesis; liver cirrhosis; synthetic products; drug therapy; dose response; males; chemoprevention; liver neoplasms; retinol-binding protein; transforming growth factor alpha; rats; cell proliferation; retinoids; apoptosis; anticarcinogenic activity
- ... We investigated the preventive effects of a synthetic acyclic retinoid, NIK-333, on the early and late events of hepatocarcinogenesis in male F344 rats treated with 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB). NIK-333 was administered once a day on consecutive days at a dose of 10, 40, or 80 mg/kg body weight along with the supplementation with 3'-MeDAB-containing diet for 16 wk. Animals from e ...