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- Gilbert, Donald L., et al. Show all 24 Authors
- Science 2005 v.310 no.5746 pp. 317-320
- binding sites; brain; children; chromosome inversions; chromosomes; frameshift mutation; genes; messenger RNA; microRNA; mutants; neurons
- ... Tourette's syndrome (TS) is a genetically influenced developmental neuropsychiatric disorder characterized by chronic vocal and motor tics. We studied Slit and Trk-like 1 (SLITRK1) as a candidate gene on chromosome 13q31.1 because of its proximity to a de novo chromosomal inversion in a child with TS. Among 174 unrelated probands, we identified a frameshift mutation and two independent occurrences ...