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You searched for: Publication Year 2004 Remove constraint Publication Year: 2004 Subject antagonists Remove constraint Subject: antagonists Subject cell membranes Remove constraint Subject: cell membranes
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1. Activity-Dependent Internalization of Smoothened Mediated by [beta]-Arrestin 2 and GRK2

Author:
Chen, Wei; Ren, Xiu-Rong; Nelson, Christopher D.; Barak, Larry S.; Chen, James K.; Beachy, Philip A.; de Sauvage, Frederic; Lefkowitz, Robert J.
Source:
Science 2004 v.306 no.5705 pp. 2257-2260
ISSN:
0036-8075
Subject:
G-protein coupled receptors; agonists; antagonists; cell membranes; cyclopamine; endocytosis; green fluorescent protein; mammals; phosphorylation
Abstract:
... Binding of Sonic Hedgehog (Shh) to Patched (Ptc) relieves the latter's tonic inhibition of Smoothened (Smo), a receptor that spans the cell membrane seven times. This initiates signaling which, by unknown mechanisms, regulates vertebrate developmental processes. We find that two molecules interact with mammalian Smo in an activation-dependent manner: G protein-coupled receptor kinase 2 (GRK2) lead ...
DOI:
10.1126/science.1104135

2. Characteristics of taurine release induced by free radicals in mouse hippocampal slices

Author:
Saransaari, P.; Oja, S. S.
Source:
Amino acids 2004 v.26 no.1 pp. 91-98
ISSN:
0939-4451
Subject:
adenosine; adults; agonists; antagonists; cell membranes; glutamic acid; hippocampus; hydrogen peroxide; hydroxylamine; ischemia; mice; neuroprotective effect; nitric oxide; receptors; taurine; transporters; tritium
Abstract:
... The release of the inhibitory neuromodulator taurine in the hippocampus is markedly enhanced under various neural cell-damaging conditions, including ischemia and exposure to free radicals. The properties and regulation of the release evoked by a medium containing free radicals was investigated in hippocampal slices from adult (3-month-old) and developing (7-day-old) mice, using a superfusion syst ...
DOI:
10.1007/s00726-003-0004-1