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- De Guise, Sylvain; Levin, Milton Jay
- Veterinary immunology and immunopathology 2004 v.97 no.3-4 pp. 177-186
- lymph nodes, etc ; Canine distemper virus; Phocoena phocoena; Tursiops truncatus; canine distemper; cell-mediated immunity; humoral immunity; immune response; lymphocytes; marine mammals; mice; models; mortality; neonates; pathogenesis; pathogens; secondary immunization; severe combined immunodeficiency; spleen; vaccination; vaccine development; vaccines; Show all 22 Subjects
- ... Morbillivirus infections have been responsible for mass mortalities in several species of marine mammals. Nevertheless, relatively little is known on the pathogenesis of the disease and the immune response to the agent, especially in cetaceans, hindering the treatment of individuals and the development of appropriate vaccines, given the difficulty of performing experimental work in marine mammals. ...
- Bendixsen, T.; Windon, R.G.; Huntley, J.F.; MacKellar, A.; Davey, R.J.; McClure, S.J.; Emery, D.L.
- Veterinary immunology and immunopathology 2004 v.97 no.1-2 pp. 11-24
- lymph nodes, etc ; Merino; Trichostrongylus colubriformis; Western blotting; ammonium sulfate; antigens; colostrum; enzyme-linked immunosorbent assay; ewes; genes; immunoglobulin A; immunoglobulin E; immunoglobulin G; immunoglobulin M; jejunum; lambs; larvae; mast cells; mice; monoclonal antibodies; necropsy; plasma cells; pretreatment; protein binding; tissues; Show all 25 Subjects
- ... The J558L cell line, previously transfected with the ovine Cε gene, was induced to secrete a chimeric IgE protein composed of the ovine heavy chain and a mouse light chain with MW of approximately 80 and 26 kDa, respectively. After purification, the chimeric protein was used to immunise BALB-c mice and monoclonal antibodies (mAbs) were generated. The mAb 2F1, which had greatest anti-IgE activity i ...